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产品介绍 Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 and SIRT2 inhibitor as well as an activator of the p53 pathway. Studies show that Tenovin-6 increases p53 levels more than Tenovin-1 and is also more toxic to yeast. Tenovin-6 has also been shown to inhibit SIRT3.
询价背景介绍 Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2), two important members of the sirtuin family. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. An improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SIRT1 and SIRT2 with IC50 values of 21 µM and 10 µM respectively. 产品介绍 Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination.
询价背景介绍 Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2), two important members of the sirtuin family. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. An improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SIRT1 and SIRT2 with IC50 values of 21 µM and 10 µM respectively. 产品介绍 Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination.
询价背景介绍 Tenovin-1, a small molecule discovered by a cell-based screen, is a bio-active activator of p53 that elevates the levels of p53 protein, p53-downstream target p21CIP/WAF1 protein and mRNA and protects p53 from mdm2-mediated degradation with little impact on p53 synthesis. Tenovin-1 also exerts inhibition against human sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2), two important members of the sirtuin family. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. An improved and water-soluble version of tenovin-1 has been found to decrease the peptide deacetylase activity of human SIRT1 and SIRT2 with IC50 values of 21 µM and 10 µM respectively. 产品介绍 Tenovin-1 inhibits the protein-deacetylating activities of SIRT1 and SIRT2. Tenovin-1 is also a p53 activator and elevates the amount of p53 protein within 2 hr of treatment, without altering p53 mRNA levels. Tenovin-1 protects against MDM2-mediated p53 degradation via ubiquitination.
询价背景介绍 Tadalafil is a small-molecule inhibitor of phosphodiesterase 5 (PDE5), a predominant PDE in the pulmonary vasculature that hydrolyzes cyclic guanosine monophosphate (cGMP) and is involved in the pathobiology of pulmonary arterial hypertension (PAH). Although it is used for the treatment of erectile dysfunction through oral administration, tadalafil also improves the vasoconstrictive-predominate condition of PAH through elevating cGMP levels in pulmonary vessels resulted from PDE5 inhibition. 产品介绍 Tadalafil, also known as IC351 or Cialis, is a potent, reversible and competitive small-molecule inhibitor of PDE5
询价背景介绍 Tadalafil is a small-molecule inhibitor of phosphodiesterase 5 (PDE5), a predominant PDE in the pulmonary vasculature that hydrolyzes cyclic guanosine monophosphate (cGMP) and is involved in the pathobiology of pulmonary arterial hypertension (PAH). Although it is used for the treatment of erectile dysfunction through oral administration, tadalafil also improves the vasoconstrictive-predominate condition of PAH through elevating cGMP levels in pulmonary vessels resulted from PDE5 inhibition. 产品介绍 Tadalafil, also known as IC351 or Cialis, is a potent, reversible and competitive small-molecule inhibitor of PDE5
询价背景介绍 Tadalafil is a small-molecule inhibitor of phosphodiesterase 5 (PDE5), a predominant PDE in the pulmonary vasculature that hydrolyzes cyclic guanosine monophosphate (cGMP) and is involved in the pathobiology of pulmonary arterial hypertension (PAH). Although it is used for the treatment of erectile dysfunction through oral administration, tadalafil also improves the vasoconstrictive-predominate condition of PAH through elevating cGMP levels in pulmonary vessels resulted from PDE5 inhibition. 产品介绍 Tadalafil, also known as IC351 or Cialis, is a potent, reversible and competitive small-molecule inhibitor of PDE5
询价背景介绍 Streptozocin, also known as streptozotocin and U-9889, is a small molecule, N-nitroso-containing antibiotic and a potent DNA methylating agent. Streptozocin acts as a nitric oxide (NO) donor and vasorelaxant. In rat cell studies, this compound presented significant methylation of the liver, kidney, and pancreatic cells and selectivity for these cells against the more general methylating activity of the aglycone analog N-methyl-N-nitrosourea . Streptozocin shows particular activity in the pancreas, and has been used both to induce diabetes in mammals and to treat human pancreatic cancers. 产品介绍 Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.
询价背景介绍 Streptozocin, also known as streptozotocin and U-9889, is a small molecule, N-nitroso-containing antibiotic and a potent DNA methylating agent. Streptozocin acts as a nitric oxide (NO) donor and vasorelaxant. In rat cell studies, this compound presented significant methylation of the liver, kidney, and pancreatic cells and selectivity for these cells against the more general methylating activity of the aglycone analog N-methyl-N-nitrosourea . Streptozocin shows particular activity in the pancreas, and has been used both to induce diabetes in mammals and to treat human pancreatic cancers. 产品介绍 Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.
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